New control of the senescence barrier in breast cancer
Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the contro...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-03-01
|
| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1684129 |
| _version_ | 1797677133877739520 |
|---|---|
| author | Tânia D. F. Costa Staffan Strömblad |
| author_facet | Tânia D. F. Costa Staffan Strömblad |
| author_sort | Tânia D. F. Costa |
| collection | DOAJ |
| description | Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the control of senescence in breast cancer, via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit RELB and the CCAAT-enhancer-binding protein beta (C/EBPβ). |
| first_indexed | 2024-03-11T22:40:32Z |
| format | Article |
| id | doaj.art-2882f433756f46b09af456ad355a1356 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:32Z |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-2882f433756f46b09af456ad355a13562023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-03-017210.1080/23723556.2019.16841291684129New control of the senescence barrier in breast cancerTânia D. F. Costa0Staffan Strömblad1Karolinska InstitutetKarolinska InstitutetNormal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the control of senescence in breast cancer, via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit RELB and the CCAAT-enhancer-binding protein beta (C/EBPβ).http://dx.doi.org/10.1080/23723556.2019.1684129cellular senescencep21-activated kinasepak4relbcebpb |
| spellingShingle | Tânia D. F. Costa Staffan Strömblad New control of the senescence barrier in breast cancer Molecular & Cellular Oncology cellular senescence p21-activated kinase pak4 relb cebpb |
| title | New control of the senescence barrier in breast cancer |
| title_full | New control of the senescence barrier in breast cancer |
| title_fullStr | New control of the senescence barrier in breast cancer |
| title_full_unstemmed | New control of the senescence barrier in breast cancer |
| title_short | New control of the senescence barrier in breast cancer |
| title_sort | new control of the senescence barrier in breast cancer |
| topic | cellular senescence p21-activated kinase pak4 relb cebpb |
| url | http://dx.doi.org/10.1080/23723556.2019.1684129 |
| work_keys_str_mv | AT taniadfcosta newcontrolofthesenescencebarrierinbreastcancer AT staffanstromblad newcontrolofthesenescencebarrierinbreastcancer |