Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis. In the context of airway viral infection, BRD4-specific inhibitors (BRD4i) block the release of pro-inflammatory cytok...

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Bibliographic Details
Main Authors: Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
BRD4
innate inflammatory response
alternative splicing
unfolded protein response
IFRD1
RSV (respiratory syncytial virus)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212770/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212770/full

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