Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms

Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms

Biologics have the potential to induce an immune response when used therapeutically. A number of in vitro assays are currently used preclinically to predict the risk of immunogenicity, but the validation of these preclinical tools suffers from the relatively small number of accessible immunogenic mo...

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Bibliographic Details
Main Authors: Robin E. Walsh, Megan Lannan, Yi Wen, Xiaoli Wang, Christopher A. Moreland, Jill Willency, Michael D. Knierman, Laura Spindler, Ling Liu, Wei Zeng, Guilherme V. Rocha, Victor Obungu, Jirong Lu, Arunan Kaliyaperumal, Andrea Ferrante, Robert Siegel, Laurent P. Malherbe
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Immunogenicity
CD4 T helper cell proliferation
suppressor CD8 T cells
dendritic cells
danger signal
internalization
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1764829

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https://www.tandfonline.com/doi/10.1080/19420862.2020.1764829

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