Camptothecin bioprocessing from Aspergillus terreus, an endophyte of Catharanthus roseus: antiproliferative activity, topoisomerase inhibition and cell cycle analysis

Abstract Attenuation of camptothecin (CPT) productivity by fungi with preservation and subculturing is the challenge that halts fungi to be an industrial platform of CPT production. Thus, screening for novel endophytic fungal isolates with metabolic stability for CPT production was the objective. Ca...

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Bibliographic Details
Main Authors: Ashraf S. A. El-Sayed, Abdelaleim I. ElSayed, Khalid M. Wadan, Sayed S. El-Saadany, Nouran A. A. Abd El-Hady
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Microbial Cell Factories
Subjects:
Online Access:https://doi.org/10.1186/s12934-023-02270-4