LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

The Mre11-Rad50-Nbs1 protein complex is one of the first responders to DNA double-strand breaks. Studies have shown that the catalytic activities of the evolutionarily conserved Mre11-Rad50 (MR) core complex depend on an ATP-dependent global conformational change that takes the macromolecule from an...

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Bibliographic Details
Main Authors: Marella D Canny, Michael P Latham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
P. furiosus
Mre11-Rad50
lanthanide resonance energy transfer
DNA damage repair
DNA double-strand break repair
Online Access:https://elifesciences.org/articles/69579

Internet

https://elifesciences.org/articles/69579

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