Structure-Activity Relationships of Substituted 2,3,4,4a,5,10b-Hexahydro-benz[h]isoquinoline-6(1H)-ones as 5-HT2c Receptor Antagonists

Structure-Activity Relationships of Substituted 2,3,4,4a,5,10b-Hexahydro-benz[h]isoquinoline-6(1H)-ones as 5-HT2c Receptor Antagonists

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A series of cis and trans configured 2,3,4,4a,5,10b-hexahydro-benz[h]isoquinoline-6(1H)-ones 2 were studied with respect to the binding affinity to the 5-HT2 subtype receptors. The influence of substituents in positions 7(R1), 8(R2) and 9(R3) on affinity and selectivity to 5-HT2A and 5-HT2...

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Bibliographic Details
Main Authors: Heinz Stadler, Jürgen Wichmann, Andrew J. Sleight, Michael Bös
Format: Article
Language:deu
Published: Swiss Chemical Society 2000-11-01
Series:CHIMIA
Subjects:
5-ht2c receptor antagonists
O-methylasparvenone
Pharmaceutical chemistry
Serotonin
Stereoselective synthesis
Online Access:https://www.chimia.ch/chimia/article/view/3309

Internet

https://www.chimia.ch/chimia/article/view/3309

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