Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

Monocrotaline (MCT), a major pyrrolizidine alkaloid, is well-known for its high liver toxicity. Dysregulation of autophagy induced apoptosis can lead to various liver diseases, including those induced by chemical compounds. Therefore, we aim to explore whether autophagy might serve as a potential st...

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Bibliographic Details
Main Authors: Yazhou Guo, Yang Yuan, Ruibo Wang, Jun Bai, Yanqing Jia, Xinxin Qiu, Huafeng Niu, Long Li, Yan Luo, Baoyu Zhao, Zhencang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
monocrotaline
hepatotoxicity
autophagy
PI3K/Akt/mTOR signaling pathway
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1499116/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1499116/full

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