Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV replication initiates in one of these cells, systemic viral spre...

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Bibliographic Details
Main Authors: Florencia A. Tettamanti Boshier, Daniel B. Reeves, Elizabeth R. Duke, David A. Swan, Martin Prlic, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Virus Eradication
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664022000292

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http://www.sciencedirect.com/science/article/pii/S2055664022000292

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