Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut microbiota

Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut microbiota

Polygonatum rhizoma polysaccharide (PP) is a main ingredient of Polygonatum rhizoma, which is both food and traditional herbal medicine. In this study, we aimed to investigate the hypoglycemic effect of PP and the underlying mechanisms in db/db mice. Our finding showed that PP significantly ameliora...

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Bibliographic Details
Main Authors: Xuan Chen, Ye-ling Tong, Ze-ming Ren, Si-si Chen, Xi-yu Mei, Qing-yun Zhou, Guan-hai Dai
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Db/db mouse
Gut microbiota
Pepck
Polygonatum rhizoma polysaccharide
Type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023026919

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http://www.sciencedirect.com/science/article/pii/S2405844023026919

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