Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS

Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS

The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites (CelTOS), is highly conserved among Plasmodium species, and plays a role in the invasion of mosquito midgut cells and hepatocytes in the vertebrate host. CelTOS was identified as a potential protective antigen based...

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Bibliographic Details
Main Authors: Ishita N. Waghela, Katherine L. Mallory, Justin A. Taylor, Cosette G. Schneider, Tatyana Savransky, Chris J. Janse, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Evelina Angov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
malaria
Plasmodium falciparum
malaria vaccine
mRNA
CelTOS
lipid nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1026052/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1026052/full

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