SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis

SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis

AbstractAggravated endoplasmic reticulum stress (ERS) and apoptosis in podocytes play an important role in lupus nephritis (LN) progression, but its mechanism is still unclear. Herein, the role of SMURF1 in regulating podocytes apoptosis and ERS during LN progression were investigated. MRL/lpr mice...

Full description

Bibliographic Details
Main Authors: Xiaoyan Li, Sisi Tao, Zhiquan Xu, Yi Ren, Wei Xiang, Xiaojie He
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autoimmunity
Subjects:
Lupus nephritis
endoplasmic reticulum stress
SMURF1
YY1
cGAS/STING/IFN-1 signal axis
Online Access:https://www.tandfonline.com/doi/10.1080/08916934.2023.2281235

Internet

https://www.tandfonline.com/doi/10.1080/08916934.2023.2281235

Similar Items