Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy

Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy

PINK1/parkin-dependent mitophagy initially involves (phospho)ubiquitin-directed proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and the recruitment of autophagy adaptors to a group of ubiquitinated OMM proteins, eventually leading to autophag...

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Bibliographic Details
Main Authors: Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, Julia C. Fitzgerald, Stefan Geimer, Benedikt Westermann, Boris Macek, Philipp J. Kahle
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Autophagy Reports
Subjects:
mitochondrial outer membrane
mitophagy
parkin
proteasome
ubiquitin
Online Access:http://dx.doi.org/10.1080/27694127.2022.2143214

Internet

http://dx.doi.org/10.1080/27694127.2022.2143214

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