Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand.

Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand.

Unlike cisplatin, which forms bifunctional DNA adducts, monofunctional platinum(II) complexes bind only one strand of DNA and might target cancer without causing auditory side-effects associated with cisplatin treatment. We synthesized the monofunctional triamine-ligated platinum(II) complexes, Pt(d...

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Bibliographic Details
Main Authors: Jerry D Monroe, Heidi L Hruska, Hannah K Ruggles, Kevin M Williams, Michael E Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5841658?pdf=render

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http://europepmc.org/articles/PMC5841658?pdf=render

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