Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases

Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases

IgG4 is the least potent human IgG subclass for the FcγR-mediated antibody effector function. Paradoxically, IgG4 is also the dominant IgG subclass of pathogenic autoantibodies in IgG4-mediated diseases. Here, we show that the IgG subclass and Fc-FcγR interaction have a distinct impact on the pathog...

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Bibliographic Details
Main Authors: Yanxia Bi, Jian Su, Shengru Zhou, Yingjie Zhao, Yan Zhang, Huihui Zhang, Mingdong Liu, Aiwu Zhou, Jianrong Xu, Meng Pan, Yiming Zhao, Fubin Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
IgG4
autoantibody
desmoglein 1
ADAMTS13
Fc-FcγR interaction
Online Access:https://elifesciences.org/articles/76223

Internet

https://elifesciences.org/articles/76223

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