Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases
IgG4 is the least potent human IgG subclass for the FcγR-mediated antibody effector function. Paradoxically, IgG4 is also the dominant IgG subclass of pathogenic autoantibodies in IgG4-mediated diseases. Here, we show that the IgG subclass and Fc-FcγR interaction have a distinct impact on the pathog...
| Main Authors: | , , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
eLife Sciences Publications Ltd
2022-08-01
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| 丛编: | eLife |
| 主题: | |
| 在线阅读: | https://elifesciences.org/articles/76223 |