Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir

Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir

The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, a minor impurity of acyclovir, is described.<em> </em>Starting with commercial <em>N</em>-(9-acetyl-6-o...

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Bibliographic Details
Main Authors: Juan José Vaquero, Antonio Cosme, Andres Molina, José Luis Novella, Maria Paz Matía, Rosa M. Suárez, Julio Alvarez-Builla
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Molecules
Subjects:
nucleosides
acyclovir
drug impurities
phase transfer catalysis
Online Access:http://www.mdpi.com/1420-3049/17/8/8735

Internet

http://www.mdpi.com/1420-3049/17/8/8735

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