Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir
The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, a minor impurity of acyclovir, is described.<em> </em>Starting with commercial <em>N</em>-(9-acetyl-6-o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/8/8735 |
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| author | Juan José Vaquero Antonio Cosme Andres Molina José Luis Novella Maria Paz Matía Rosa M. Suárez Julio Alvarez-Builla |
| author_facet | Juan José Vaquero Antonio Cosme Andres Molina José Luis Novella Maria Paz Matía Rosa M. Suárez Julio Alvarez-Builla |
| author_sort | Juan José Vaquero |
| collection | DOAJ |
| description | The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, a minor impurity of acyclovir, is described.<em> </em>Starting with commercial <em>N</em>-(9-acetyl-6-oxo-1<em>H</em>-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring. |
| first_indexed | 2024-12-22T14:31:55Z |
| format | Article |
| id | doaj.art-289694840f5243f985b01445ca197ab6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T14:31:55Z |
| publishDate | 2012-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-289694840f5243f985b01445ca197ab62022-12-21T18:22:43ZengMDPI AGMolecules1420-30492012-07-011788735874110.3390/molecules17088735Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of AcyclovirJuan José VaqueroAntonio CosmeAndres MolinaJosé Luis NovellaMaria Paz MatíaRosa M. SuárezJulio Alvarez-BuillaThe synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, a minor impurity of acyclovir, is described.<em> </em>Starting with commercial <em>N</em>-(9-acetyl-6-oxo-1<em>H</em>-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.http://www.mdpi.com/1420-3049/17/8/8735nucleosidesacyclovirdrug impuritiesphase transfer catalysis |
| spellingShingle | Juan José Vaquero Antonio Cosme Andres Molina José Luis Novella Maria Paz Matía Rosa M. Suárez Julio Alvarez-Builla Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir Molecules nucleosides acyclovir drug impurities phase transfer catalysis |
| title | Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir |
| title_full | Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir |
| title_fullStr | Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir |
| title_full_unstemmed | Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir |
| title_short | Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6<em>H</em>-purin-6-one, an Impurity of Acyclovir |
| title_sort | synthesis of 9 9 1 2 ethanediylbis oxymethylene bis 2 amino 1 9 dihydro 6 lt em gt h lt em gt purin 6 one an impurity of acyclovir |
| topic | nucleosides acyclovir drug impurities phase transfer catalysis |
| url | http://www.mdpi.com/1420-3049/17/8/8735 |
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