GPR4 Knockout Attenuates Intestinal Inflammation and Forestalls the Development of Colitis-Associated Colorectal Cancer in Murine Models

GPR4 Knockout Attenuates Intestinal Inflammation and Forestalls the Development of Colitis-Associated Colorectal Cancer in Murine Models

GPR4 is a proton-sensing G protein-coupled receptor highly expressed in vascular endothelial cells and has been shown to potentiate intestinal inflammation in murine colitis models. Herein, we evaluated the proinflammatory role of GPR4 in the development of colitis-associated colorectal cancer (CAC)...

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Bibliographic Details
Main Authors: Mona A. Marie, Edward J. Sanderlin, Alexander P. Hoffman, Kylie D. Cashwell, Swati Satturwar, Heng Hong, Ying Sun, Li V. Yang
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
inflammation
cancer
inflammatory bowel disease (IBD)
colitis-associated colorectal cancer
GPR4
G protein-coupled receptor (GPCR)
Online Access:https://www.mdpi.com/2072-6694/15/20/4974

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https://www.mdpi.com/2072-6694/15/20/4974

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