Itraconazole Nanosuspensions via Dual Centrifugation Media Milling: Impact of Formulation and Process Parameters on Particle Size and Solid-State Conversion as Well as Storage Stability

Itraconazole Nanosuspensions via Dual Centrifugation Media Milling: Impact of Formulation and Process Parameters on Particle Size and Solid-State Conversion as Well as Storage Stability

Nanocrystal suspensions proved to be a potent enabling principle for biopharmaceutics classification system class II drugs with dissolution limited bioavailability. In the example of itraconazole (ITZ) as a model drug combined with electrosteric stabilization using hydroxypropyl cellulose (HPC-SL),...

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Bibliographic Details
Main Authors: Ann-Cathrin Willmann, Kai Berkenfeld, Thilo Faber, Herbert Wachtel, Georg Boeck, Karl G. Wagner
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
dual centrifugation
itraconazole
media milling
nanocrystals
nanosuspension
agglomeration
Online Access:https://www.mdpi.com/1999-4923/14/8/1528

Internet

https://www.mdpi.com/1999-4923/14/8/1528

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