Dephosphorylation of YB-1 is Required for Nuclear Localisation During G<sub>2</sub> Phase of the Cell Cycle

Dephosphorylation of YB-1 is Required for Nuclear Localisation During G<sub>2</sub> Phase of the Cell Cycle

Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. It has been proposed that entry into the nucleus requires specific proteasomal cleavage. However, evidence for cleavage is contradictory and high YB-1 levels are prognostic regardless of cellular locati...

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Bibliographic Details
Main Authors: Sunali Mehta, Cushla McKinney, Michael Algie, Chandra S. Verma, Srinivasaraghavan Kannan, Rhodri Harfoot, Tara K. Bartolec, Puja Bhatia, Alistair J. Fisher, Maree L. Gould, Kim Parker, Anthony J. Cesare, Heather E. Cunliffe, Scott B. Cohen, Torsten Kleffmann, Antony W. Braithwaite, Adele G. Woolley
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
yb-1
cell cycle
nuclear translocation
atomistic modelling
phosphorylation
Online Access:https://www.mdpi.com/2072-6694/12/2/315

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https://www.mdpi.com/2072-6694/12/2/315

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