Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGF<i>β</i>-Induced EMT in Human Non-Small Cell Lung Cancer

Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGF<i>β</i>-Induced EMT in Human Non-Small Cell Lung Cancer

Growth factors and cytokines released in the lung cancer microenvironment promote an epithelial-to-mesenchymal transition (EMT) that sustains the progression of neoplastic diseases. TGF<i>β</i> is one of the most powerful inducers of this transition, as it induces overexpression of the f...

Full description

Bibliographic Details
Main Authors: Elena Andreucci, Kelly Bugatti, Silvia Peppicelli, Jessica Ruzzolini, Matteo Lulli, Lido Calorini, Lucia Battistini, Franca Zanardi, Andrea Sartori, Francesca Bianchini
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
A549 lung cancer cells
transforming growth factor<i>β</i> (TGF<i>β</i>)
αvβ6 integrin ligands
epithelial-mesenchymal transition (EMT)
nintedanib
molecular conjugates
Online Access:https://www.mdpi.com/1422-0067/24/2/1475

Internet

https://www.mdpi.com/1422-0067/24/2/1475

Similar Items