HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.

HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.

Broadly neutralizing antibodies (bNAbs) isolated from chronically HIV-1 infected individuals reveal important information regarding how antibodies target conserved determinants of the envelope glycoprotein (Env) spike such as the primary receptor CD4 binding site (CD4bs). Many CD4bs-directed bNAbs u...

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Bibliographic Details
Main Authors: Marjon Navis, Karen Tran, Shridhar Bale, Ganesh E Phad, Javier Guenaga, Richard Wilson, Martina Soldemo, Krisha McKee, Christopher Sundling, John Mascola, Yuxing Li, Richard T Wyatt, Gunilla B Karlsson Hedestam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4148451?pdf=render

Internet

http://europepmc.org/articles/PMC4148451?pdf=render

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