Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases

Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases

1,2,3-triazoles are versatile building blocks with growing interest in medicinal chemistry. For this reason, organic chemistry focuses on the development of new synthetic pathways to obtain 1,2,3-triazole derivatives, especially with pyridine moieties. In this work, a novel series of 1,5-disubstitut...

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Bibliographic Details
Main Authors: Vincenzo Algieri, Paola Costanzo, Matteo Antonio Tallarida, Fabrizio Olivito, Antonio Jiritano, Giulia Fiorani, Francesca Peccati, Gonzalo Jiménez-Osés, Loredana Maiuolo, Antonio De Nino
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
1,2,3-triazoles
nucleobases
Lewis acid
click chemistry
molecular docking
ADME
Online Access:https://www.mdpi.com/1420-3049/27/23/8467

Internet

https://www.mdpi.com/1420-3049/27/23/8467

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