Discovery of Fungus-Specific Targets and Inhibitors Using Chemical Phenotyping of Pathogenic Spore Germination

Discovery of Fungus-Specific Targets and Inhibitors Using Chemical Phenotyping of Pathogenic Spore Germination

ABSTRACT There is a critical need for new antifungal drugs; however, the lack of available fungus-specific targets is a major hurdle in the development of antifungal therapeutics. Spore germination is a differentiation process absent in humans that could harbor uncharacterized fungus-specific target...

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Bibliographic Details
Main Authors: Sébastien C. Ortiz, Mingwei Huang, Christina M. Hull
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
Cryptococcus
antifungal agents
fungi
germination
spores
Online Access:https://journals.asm.org/doi/10.1128/mBio.01672-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01672-21

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