Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification

Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification

A highly efficient synthesis of enantiomerically pure (S) and (R)-isomers of N-(2,3-dihydroxypropyl)arylamides has been developed with good overall yields in a two step process. The key step involves the ring opening of the chiral epoxide with a nitrogen heterocyclic carbene (NHC) and further rearra...

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Bibliographic Details
Main Authors: Akula Raghunadh, Satish S More, T. Krishna Chaitanya, Yadla Sateesh Kumar, Suresh Babu Meruva, L. Vaikunta Rao, U. K. Syam Kumar
Format: Article
Language:English
Published: Beilstein-Institut 2013-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
N-(2,3-dihydroxypropyl)arylamide
nitrogen heterocyclic carbenes (NHC)
oxidative esterification of aromatic aldehyde
Online Access:https://doi.org/10.3762/bjoc.9.250

Internet

https://doi.org/10.3762/bjoc.9.250

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