Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism

Endogenous nociceptin/orphanin FQ (N/OFQ) inhibits the activity of dopamine neurons in the substantia nigra and affects motor behavior. In this study we investigated whether a N/OFQ receptor (NOP) antagonist, J-113397, can modify movement in naive mice and nonhuman primates and attenuate motor defic...

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Bibliographic Details
Main Authors: Riccardo Viaro, Rosario Sanchez-Pernaute, Matteo Marti, Claudio Trapella, Ole Isacson, Michele Morari
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neurobiology of Disease
Subjects:
J-113397
L-DOPA
MPTP
Nociceptin/orphanin FQ
NOP−/− mice
NOP receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000454

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http://www.sciencedirect.com/science/article/pii/S0969996108000454

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