Spatial organization and early signaling of the B-cell receptor in CLL

Spatial organization and early signaling of the B-cell receptor in CLL

Most chronic lymphocytic leukemia (CLL) clones express B-cell receptors (BcR) of both IgM/IgD isotypes; however, 5%–10% of CLL cases express isotype-switched immunoglobulin G (IgG). The early signaling and spatial patterning of the various BcRs at steady state and after activation are still fully un...

Full description

Bibliographic Details
Main Authors: Yamit Shorer Arbel, Yotam Bronstein, Tali Dadosh, Talia Kamdjou, Shlomo Tsuriel, Mika Shapiro, Ben-Zion Katz, Yair Herishanu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
CLL (chronic lymphocytic leukemia)
BCR signaling
IGHV mutational status
IgM
IgG
d-STORM
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.953660/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.953660/full

Similar Items