Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

Summary: In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of IFNγ-producing T cells acting through the transcriptional control of glucose utilization. High expression of survivin in CD4+T cells was associated with IFNγ-dependent phenotype and anaerobic gly...

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Bibliographic Details
Main Authors: Malin C. Erlandsson, Karin M.E. Andersson, Nina Y. Oparina, Venkataragavan Chandrasekaran, Tibor Saghy, Anastasios Damdimopoulos, Maria-Jose Garcia-Bonete, Zakaria Einbeigi, Sofia T. Silfverswärd, Marcela Pekna, Gergely Katona, Maria I. Bokarewa
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Biological sciences
Immunology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222017989

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222017989

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