Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy

Mitophagy activation is mediated by mitochondrial depolarization. Here, the authors show that mitochondrial protein misfolding can activate mitophagy in a depolarization-independent manner mediated by a protein import reduction.

Bibliographic Details
Main Authors: Jonas Benjamin Michaelis, Melinda Elaine Brunstein, Süleyman Bozkurt, Ludovico Alves, Martin Wegner, Manuel Kaulich, Christian Pohl, Christian Münch
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32564-x

Internet

https://doi.org/10.1038/s41467-022-32564-x

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