Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than palmitic acid, similar to the effects observed...

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Bibliographic Details
Main Authors: Noah M Dietzen, Mark J Arcario, Lawrence J Chen, John T Petroff II, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
ligand-gated ion channel
docosahexaenoic acid
polyunsaturated fatty acid
photoaffinity labeling
mass spectrometry
coarse-grained molecular dynamics simulations
Online Access:https://elifesciences.org/articles/74306

Internet

https://elifesciences.org/articles/74306

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