Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Abstract Macroautophagy decreases with age, and this change is considered a hallmark of the aging process. It remains unknown whether mitophagy, the essential selective autophagic degradation of mitochondria, also decreases with age. In our analysis of mitophagy in multiple organs in the mito-QC rep...

Full description

Bibliographic Details
Main Authors: Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45044-1

Internet

https://doi.org/10.1038/s41467-024-45044-1

Similar Items