Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance

Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance

Many cancer studies now recognize that disease initiation, progression, and response to treatment are strongly influenced by the microenvironmental niche. Widespread desmoplasia, or fibrosis, is fundamental to pancreatic cancer development, growth, metastasis, and treatment resistance. This fibrotic...

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Bibliographic Details
Main Authors: Kendelle J. Murphy, Cecilia R. Chambers, David Herrmann, Paul Timpson, Brooke A. Pereira
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
pancreatic cancer
stroma
tumor microenvironment
extracellular matrix
cancer-associated fibroblasts
biomechanics
Online Access:https://www.mdpi.com/2072-6694/13/14/3481

Internet

https://www.mdpi.com/2072-6694/13/14/3481

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