Inhibition of BET Proteins Regulates Fcγ Receptor Function and Reduces Inflammation in Rheumatoid Arthritis

Inhibition of BET Proteins Regulates Fcγ Receptor Function and Reduces Inflammation in Rheumatoid Arthritis

Overactivation of immune responses is a hallmark of autoimmune disease pathogenesis. This includes the heightened production of inflammatory cytokines such as Tumor Necrosis Factor α (TNFα), and the secretion of autoantibodies such as isotypes of rheumatoid factor (RF) and anticitrullinated protein...

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Bibliographic Details
Main Authors: Divya Shankar, Giovanna Merchand-Reyes, Nathaniel J. Buteyn, Ramasamy Santhanam, Huiqing Fang, Krishan Kumar, Xiaokui Mo, Latha P. Ganesan, Wael Jarjour, Jonathan P. Butchar, Susheela Tridandapani
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
FcγR
rheumatoid arthritis
monocytes
BET inhibition
Online Access:https://www.mdpi.com/1422-0067/24/8/7623

Internet

https://www.mdpi.com/1422-0067/24/8/7623

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