Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia

Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia

Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency. This study aimed to determine the effects of TLR4 on Treg differentiation and the cytokine production of periphera...

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Bibliographic Details
Main Authors: Yating Hao, Huiyuan Li, Yang Li, Mingen Lyu, Donglei Zhang, Rongfeng Fu, Yue Guan, Shixuan Wang, Boyang Sun, Xueqing Dou, Renchi Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:Autoimmunity
Subjects:
tlr4
treg
th17
th17/treg ratio
primary immune thrombocytopenia
Online Access:http://dx.doi.org/10.1080/08916934.2017.1309034

Internet

http://dx.doi.org/10.1080/08916934.2017.1309034

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