Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations

Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations

IntroductionHyperuricemia (HUA) is a metabolic disorder caused by purine metabolism dysfunction in which the increasing purine levels can be partially attributed to seafood consumption. Perillae Folium (PF), a widely used plant in functional food, has been historically used to mitigate seafood-induc...

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Bibliographic Details
Main Authors: Chuanghai Wu, Ann Rann Wong, Qinghong Chen, Shuxuan Yang, Meilin Chen, Xiaomin Sun, Lin Zhou, Yanyan Liu, Angela Wei Hong Yang, Jianlu Bi, Andrew Hung, Hong Li, Xiaoshan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
functional food
hyperuricemia
metabolomics
molecular docking
molecular dynamics simulation
in silico analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1320092/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2024.1320092/full

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