Paradoxical attenuation of neuroinflammatory response upon LPS challenge in miR-146b deficient mice

Paradoxical attenuation of neuroinflammatory response upon LPS challenge in miR-146b deficient mice

The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b (miR-146a/b), both of which are known to suppress immune responses in a variety of conditions. Here, we studied how constitutive deficiency of miR-146b (Mir146b-/-) affects lipopolysaccharide (LPS)-induced neuroinflammation...

Full description

Bibliographic Details
Main Authors: Keerthana Chithanathan, Monika Jürgenson, Mithu Guha, Ling Yan, Tamara Žarkovskaja, Martin Pook, Nathaniel Magilnick, Mark P. Boldin, Ana Rebane, Li Tian, Alexander Zharkovsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
miRNAs
miR-146b deficiency
attenuated neuroinflammation
miR-146a upregulation
miR-146a/b crosstalk
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.996415/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.996415/full

Similar Items