Can BioSAXS detect ultrastructural changes of antifungal compounds in Candida albicans?–an exploratory study

Can BioSAXS detect ultrastructural changes of antifungal compounds in Candida albicans?–an exploratory study

The opportunistic yeast Candida albicans is the most common cause of candidiasis. With only four classes of antifungal drugs on the market, resistance is becoming a problem in the treatment of fungal infections, especially in immunocompromised patients. The development of novel antifungal drugs with...

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Bibliographic Details
Main Authors: Kai Hilpert, Christoph Rumancev, Jurnorain Gani, Dominic W. P. Collis, Paula Matilde Lopez-Perez, Vasil M. Garamus, Ralf Mikut, Axel Rosenhahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
Candida albicans
antifungal peptides
antimicrobial peptides
BioSAXS
SAXS (small-angle X-ray scattering)
mode of action (MOA)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1141785/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1141785/full

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