Case Report: Identification of a CARD8 variant in all three patients with PFAPA syndrome complicated with Kawasaki disease

Case Report: Identification of a CARD8 variant in all three patients with PFAPA syndrome complicated with Kawasaki disease

BackgroundPeriodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome), and Kawasaki disease (KD) are both considered to be disorders of the innate immune system, and the potential role of inflammasome activation in the immunopathogenesis of both diseases has been previou...

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Bibliographic Details
Main Authors: Haruhiko Nakamura, Atsuo Kikuchi, Hideyuki Sakai, Miki Kamimura, Yohei Watanabe, Ryoichi Onuma, Jun Takayama, Gen Tamiya, Yoichi Mashimo, Ryota Ebata, Hiromichi Hamada, Tomohiro Suenaga, Yoshihiro Onouchi, Satoru Kumaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pediatrics
Subjects:
CARD8
inflammasome
NLRP3
inflammatory dysregulation
Kawasaki disease
PFAPA syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2024.1340263/full

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https://www.frontiersin.org/articles/10.3389/fped.2024.1340263/full

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