RIPK3‐mediated cell death is involved in DUX4‐mediated toxicity in facioscapulohumeral dystrophy

RIPK3‐mediated cell death is involved in DUX4‐mediated toxicity in facioscapulohumeral dystrophy

Abstract Background Facioscapulohumeral dystrophy (FSHD) is caused by mutations leading to the aberrant expression of the DUX4 transcription factor in muscles. DUX4 was proposed to induce cell death, but the involvement of different death pathways is still discussed. A possible pro‐apoptotic role of...

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Bibliographic Details
Main Authors: Virginie Mariot, Romain Joubert, Laura Le Gall, Eva Sidlauskaite, Christophe Hourde, William Duddy, Thomas Voit, Maximilien Bencze, Julie Dumonceaux
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
FSHD
DUX4
Necroptosis
Ripk3
Facioscapulohumeral dystrophy
Online Access:https://doi.org/10.1002/jcsm.12813

Internet

https://doi.org/10.1002/jcsm.12813

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