Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1

Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1

Summary: Lymphocyte trafficking requires fine-tuning of chemokine-mediated cell migration. This process depends on cytoskeletal dynamics and polarity, but its regulation remains elusive. We quantitatively measured cell polarity and revealed critical roles performed by integrin activator Rap1 in this...

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Bibliographic Details
Main Authors: Yoshihiro Ueda, Koichiro Higasa, Yuji Kamioka, Naoyuki Kondo, Shunsuke Horitani, Yoshiki Ikeda, Wolfgang Bergmeier, Yoshinori Fukui, Tatsuo Kinashi
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Cellular physiology
Molecular interaction
Cell
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422301369X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422301369X

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