Pre-Existing Humoral Immunological Memory Is Retained in Patients with Multiple Sclerosis Receiving Cladribine Therapy

Pre-Existing Humoral Immunological Memory Is Retained in Patients with Multiple Sclerosis Receiving Cladribine Therapy

Cladribine (CLAD) is a lymphodepleting agent approved for active relapsing multiple sclerosis (MS). The impact of CLAD on the adaptive humoral immune system has not sufficiently been studied. This study aimed to assess the influence of CLAD treatment on specific antibody titers to common pathogens....

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Bibliographic Details
Main Authors: Tobias Moser, Ciara O’Sullivan, Christian Puttinger, Julia Feige, Georg Pilz, Elisabeth Haschke-Becher, Janne Cadamuro, Hannes Oberkofler, Wolfgang Hitzl, Andrea Harrer, Jörg Kraus, Eugen Trinka, Peter Wipfler
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomedicines
Subjects:
vaccination
lymphodepletion
immune reconstitution
titers
immunization
antibody levels
Online Access:https://www.mdpi.com/2227-9059/9/11/1584

Internet

https://www.mdpi.com/2227-9059/9/11/1584

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