Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy

Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy

IntroductionPost translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which permits the presentation of modified epitopes upon M...

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Bibliographic Details
Main Authors: Victoria Anne Brentville, Peter Symonds, JiaXin Chua, Anne Skinner, Ian Daniels, Katherine Wendy Cook, Sasa Koncarevic, Roxana Martinez-Pinna, Sabaria Shah, Ruhul Hasan Choudhury, Poonam Vaghela, Daisy Weston, Abdullah Al-Omari, James Davis, Lindy G. Durrant
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
citrullination
cancer
MHC-II
post-translation modifications
GRP78
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066185/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066185/full

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