Tetramisole is a new IK1 channel agonist and exerts IK1‐dependent cardioprotective effects in rats

Tetramisole is a new IK1 channel agonist and exerts IK1‐dependent cardioprotective effects in rats

Abstract Cardiac ischemia, hypoxia, arrhythmias, and heart failure share the common electrophysiological changes featured by the elevation of intracellular Ca2+ (Ca2+ overload) and inhibition of the inward rectifier potassium (IK1) channel. IK1 channel agonists have been considered a new type of ant...

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Bibliographic Details
Main Authors: Qinghua Liu, Jiaxing Sun, Yangdou Dong, Pan Li, Jin Wang, Yulan Wang, Yanwu Xu, Xinrui Tian, Bowei Wu, Peifeng He, Qi Yu, Xuechun Lu, Jimin Cao
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Pharmacology Research & Perspectives
Subjects:
arrhythmia
calcium overload
cardiac remodeling
drug repurposing
inward rectifier potassium channel
molecular docking
Online Access:https://doi.org/10.1002/prp2.992

Internet

https://doi.org/10.1002/prp2.992

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