Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer’s Disease

Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer’s Disease

Silence information regulator 3 (SIRT3) is an NAD+ dependent deacetylase enzyme that enhances the function of key mitochondrial proteins. We have earlier demonstrated that deletion of Sirt3 gene leads to downregulation of metabolic enzymes, mitochondrial dysfunction and neuroinflammation in the brai...

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Bibliographic Details
Main Authors: Alpna Tyagi, Carol Mirita, Iman Shah, P. Hemachandra Reddy, Subbiah Pugazhenthi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
blood brain barrier
brain micro endothelial cells
lipotoxicity
inflammation
sirt3
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.716616/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.716616/full

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