The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability

We report increased cholesterol efflux from macrophages in the presence of falcarindiol, an important dietary constituent present in commonly used vegetables and medicinal plants. Falcarindiol (3–20 μM) increased cholesterol efflux from THP-1-derived macrophages. Western blot analysis showed an incr...

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Bibliographic Details
Main Authors: Limei Wang, Veronika Palme, Nicole Schilcher, Angela Ladurner, Elke H. Heiss, Herbert Stangl, Rudolf Bauer, Verena M. Dirsch, Atanas G. Atanasov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
falcarindiol
cholesterol efflux
ABCA1
protein degradation
PPARγ
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00596/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00596/full

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