Naturally Occurring Bicoumarin Compound Daphnoretin Inhibits Growth and Induces Megakaryocytic Differentiation in Human Chronic Myeloid Leukemia Cells

Naturally Occurring Bicoumarin Compound Daphnoretin Inhibits Growth and Induces Megakaryocytic Differentiation in Human Chronic Myeloid Leukemia Cells

Daphnoretin extracted from the stem and roots of <i>Wikstroemia indica</i> (L.) C.A. Mey has been shown to possess antiviral and antitumor activities. Herein, we hypothesized that daphnoretin might induce megakaryocytic differentiation, thereby inhibiting the proliferation of cells and s...

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Bibliographic Details
Main Authors: Yu-Chuen Huang, Chun-Ping Huang, Chin-Ping Lin, Kai-Chien Yang, Yu-Jie Lei, Hao-Pei Wang, Yueh-Hsiung Kuo, Yu-Jen Chen
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
daphnoretin
differentiation
megakaryocyte
protein kinase C
myeloid leukemia
Online Access:https://www.mdpi.com/2073-4409/11/20/3252

Internet

https://www.mdpi.com/2073-4409/11/20/3252

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