Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells

Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells

Docosahexaenoic acid (DHA, 22:6n-3) is a unique polyunsaturated fatty acid particularly abundant in nerve cell membrane phospholipids. DHA is a pleiotropic molecule that, not only modulates the physicochemical properties and architecture of neuronal plasma membrane, but it is also involved in multi...

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Bibliographic Details
Main Authors: Veronica eCasañas-Sanchez, José Antonio Pérez, Noemi eFabelo, David eQuinto-Alemany, Mario L Diaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Physiology
Subjects:
Neuroprotection
Transcriptional regulation
docosahexaenoic acid
glutathione peroxidase 4
Intron retention
hippocampal cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00203/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00203/full

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