Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity

Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity

Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production. In most cases, dysregulation of the plasma kallikrein-kinin system due to deficiency of plasma C1 inhibitor is the underlying cause. However, at least...

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Bibliographic Details
Main Authors: Aleksandr Shamanaev, S. Kent Dickeson, Ivan Ivanov, Maxim Litvak, Mao-Fu Sun, Sunil Kumar, Quifang Cheng, Priyanka Srivastava, Tracey Z. He, David Gailani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Physiology
Subjects:
hereditary angioedema
kallikrein-kinin system
kallikrein
factor XII
plasminogen
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1146834/full

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https://www.frontiersin.org/articles/10.3389/fphys.2023.1146834/full

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