Liver Fibrosis Stages Affect Organic Cation Transporter 1/2 Activities in Hepatitis C Virus-Infected Patients

Liver Fibrosis Stages Affect Organic Cation Transporter 1/2 Activities in Hepatitis C Virus-Infected Patients

This study aims to evaluate the impact of liver fibrosis stages of chronic infection with hepatitis C virus (HCV) on the in vivo activity of organic cation transporters (hepatic OCT1 and renal OCT2) using metformin (MET) as a probe drug. Participants allocated in Group 1 (<i>n</i> = 15,...

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Bibliographic Details
Main Authors: Matheus De Lucca Thomaz, Carolina Pinto Vieira, Juciene Aparecida Caris, Maria Paula Marques, Adriana Rocha, Tiago Antunes Paz, Rosamar Eulira Fontes Rezende, Vera Lucia Lanchote
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Pharmaceuticals
Subjects:
chronic hepatitis C
metformin
organic cation transporter
inflammation
pharmacokinetics
liver fibrosis
Online Access:https://www.mdpi.com/1424-8247/17/7/865

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https://www.mdpi.com/1424-8247/17/7/865

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