TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report

TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report

SCLC transformation in EGFR-mutated lung adenocarcinoma is one of the major phenotypic changes that is observed during the resistance to EGFR tyrosine kinase inhibitors. However, the mechanism of this transformation remains unclear. In this study, we found a small de novo SCLC component in surgicall...

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Bibliographic Details
Main Authors: Kei Kunimasa, MD, PhD, Yosuke Hirotsu, PhD, Kenji Amemiya, MSH, Harumi Nakamura, MD, PhD, Kazumi Nishino, MD, PhD, Keiichiro Honma, MD, PhD, Jiro Okami, MD, PhD, Masao Omata, MD, PhD, Toru Kumagai, MD, PhD
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:JTO Clinical and Research Reports
Subjects:
EGFR-mutated lung adenocarcinoma
Small cell lung cancer
Transformation
TP53 mutation
Loss of heterozygosity
Case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364322000297

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http://www.sciencedirect.com/science/article/pii/S2666364322000297

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